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Surgical treatment of neuroblastomas in infants under 12 months of age
H Ikeda1, N Suzuki, A Takahashi
1Department of Surgery, Gunma Children's Medical Center, Gunma University Hospital, Japan.
Insights
Surgical treatment for infant neuroblastoma is debated due to potential spontaneous regression. Aggressive surgery is not recommended for favorable tumors, balancing treatment risks against tumor regression potential.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Neuroblastoma Research
Background:
- Surgical management of neuroblastoma in infants under 12 months is controversial.
- Potential for spontaneous tumor regression exists in this age group.
Purpose of the Study:
- To evaluate surgical outcomes for neuroblastoma in infants.
- To compare screening-detected versus clinically detected neuroblastoma in infants.
Main Methods:
- Retrospective analysis of 50 infants (under 1 year) treated between 1985 and 1997.
- Categorization into screening-detected (41 cases) and clinically detected (9 cases).
- Assessment of tumor stage, biological characteristics, surgical resection, and complications.
Main Results:
- Complete resection achieved in 92% of patients.
- No significant difference in biological characteristics between screening- and clinically-detected tumors.
- High survival rate (98%), with one death due to surgical complications.
Conclusions:
- Aggressive surgery for biologically favorable infant neuroblastoma is not advised.
- Treatment risks must be weighed against the potential for spontaneous tumor regression.
- Careful consideration is needed for surgical intervention in this population.
Background:
Surgical treatment of neuroblastomas, both those detected by screening and those detected clinically, in infants less than 12 months of age, is controversial, because some tumors in this age group potentially have the ability to regress spontaneously.
Methods:
From January 1985 to March 1997, the authors treated 50 infants (under 1 year of age) with neuroblastoma: 23 boys and 27 girls. Forty-one cases were detected preclinically by screening when the patients were 6 to 11 months of age (median, 7 months), and nine patients were discovered to have clinical manifestations at the age of 1 to 10 months (median, 4 months).
Results:
The tumor was INSS stage 3 or 4 in 10 patients (24%) with screening-detected tumor and in five (56%) with clinically detected tumor, although the difference was not statistically significant. Four screening-positive patients had multifocal primary tumors, and three of them were synchronous bilateral adrenal neuroblastomas. There was no statistically significant difference between the screening-detected tumors and the clinically detected tumors in biological characteristics such as Shimada's histology, DNA ploidy, and N-myc amplification. Complete resection of the primary lesion was accomplished by either primary surgery or second look (delayed primary) surgery in 46 patients (92%), and the resection was incomplete in the remaining four. In patients with bilateral adrenal tumors, the larger one was primarily resected, and the smaller contralateral tumor was enucleated or resected by partial adrenalectomy. Surgical complications included postoperative adhesive ileus (n=2), Horner's syndrome (n=2), renal atrophy (n=1), renal failure (n=1), phrenic nerve injury (n=1), chylous ascites (n=1), chylothorax (n=1) and intussusception (n=1). One patient died of respiratory failure caused by a complication, but 49 patients (98%) were alive at the time of evaluation.
Conclusion:
When considering surgical treatment of infants with biologically favorable neuroblastoma, the risk involved in treatment should be weighed against the risk inherent in a tumor capable of spontaneous regression, and aggressive surgery is unacceptable.