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Related Experiment Videos

Single or triple dose piperacillin prophylaxis in elective cesarean section

S Shah1, Y Mazher, I S John

  • 1Department of Obstetrics and Gynecology, Corniche Hospital, Abu-Dhabi, United Arab Emirates.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|August 29, 1998
PubMed
Summary

Piperacillin effectively prevents febrile morbidity after cesarean sections. This antibiotic prophylaxis, given as a single or multiple dose, demonstrated significant safety and efficacy in preventing postoperative infections.

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pharmacology

Background:

  • Postoperative febrile morbidity is a significant concern following cesarean sections.
  • Antibiotic prophylaxis is commonly used to prevent surgical site infections.

Purpose of the Study:

  • To evaluate the efficacy and safety of piperacillin for preventing perioperative febrile morbidity in elective cesarean sections.
  • To compare piperacillin with a combination of cephradine plus metronidazole and a control group receiving no antibiotic prophylaxis.

Main Methods:

  • A randomized control study involving 184 women undergoing elective cesarean sections.
  • Comparison of single-dose (4 g) or three-dose (2 g) piperacillin, three-dose cephradine plus metronidazole, and a no-prophylaxis control group.

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  • Perioperative administration of all prophylactic antibiotic regimens.

    • Main Results:

    • Piperacillin (single and multi-dose) significantly reduced postoperative febrile morbidity compared to the control group (RR=0.14-0.27).
    • The cephradine plus metronidazole combination did not show a statistically significant difference compared to the control (RR=0.49).
    • Piperacillin demonstrated a trend towards greater efficacy with a single dose versus multi-dose, though not statistically significant (RR=0.51).

    Conclusions:

    • Single-agent piperacillin therapy, administered as a single 4g dose or a triple 2g dose, is effective and safe.
    • Piperacillin serves as a valuable prophylactic agent for preventing postoperative infections in elective cesarean sections.