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The IGF system during fetal-placental development of the mouse
M van Kleffens1, C Groffen, D J Lindenbergh-Kortleve
1Department of Pediatrics, Erasmus University Rotterdam, The Netherlands. vankleffens@pa1.fgg.eur.nl
Molecular and Cellular Endocrinology
|August 29, 1998
Abstract:
Insulin-like growth factors (IGF-I and -II) promote cellular mitosis and differentiation and have been implicated in fetal and placental growth. Together with the IGF receptors and IGF binding proteins (IGFBPs) they form a complex network, with tissue specific activity. This review will discuss the data generated to elucidate the functions of the IGF system during mouse development.