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T-cell-independent antiviral antibody responses
E Szomolanyi-Tsuda1, R M Welsh
1Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA. Eva.Szomolanyi-Tsuda@banyan.ummed.edu
Current Opinion in Immunology
|September 2, 1998
Abstract:
Recent work has shown that viruses can act in vivo as T-cell-independent antigens, eliciting protective, isotype-switched antibodies in the absence of conventional TCR alpha beta+ T cell help. Inactivated virus or virus-like particles can stimulate IgM production, but factors induced during live virus infection appear to be required to induce the isotype switch that leads to IgG or IgA responses.