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Cytotoxic T cell responses to intracellular pathogens

S Stenger1, R L Modlin

  • 1Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universität Erlangen, Germany.

Current Opinion in Immunology
|September 2, 1998
PubMed

Host defense against intracellular pathogens is thought to require cytotoxic T cells. Recent studies have investigated the impact of host cell lysis and cytokine production by cytotoxic T lymphocytes on the fate of intracellular pathogens. The identification of two mechanisms of lysis induced by cytotoxic T lymphocytes--the granule exocytosis pathway and the Fas-FasL interaction--have provided new insight into the role of cytotoxic T lymphocyters in immunity to infection.

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