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Carica papaya pollen allergy

C Blanco¹, N Ortega, R Castillo

¹Section of Allergy, Hospital Universitario Ntra. Sra. del Pino, Las Palmas de Gran Canaria, Canary Islands, Spain.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|September 2, 1998

Summary

Carica papaya pollen can cause respiratory allergies. This study found common allergens in papaya pollen, fruit, and papain, demonstrating cross-reactivity in allergic patients.

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Area of Science:

Allergy and Immunology
Environmental Health
Botany

Background:

Carica papaya (CP) cultivation is widespread globally.
CP pollen allergy remains undescribed despite extensive cultivation.

Observation:

Patients presented with symptoms of seasonal rhinoconjunctivitis or bronchial asthma linked to CP tree exposure.
Skin prick tests (SPTs) and specific IgE levels indicated hypersensitivity to papaya fruit and papain.

Findings:

An IgE-mediated hypersensitivity to CP pollen extract was confirmed in all six patients via SPTs, IgE tests, and conjunctival challenge tests.
Cross-reactivity between CP pollen, papaya fruit, and papain allergens was established through RAST inhibition studies.
Control subjects showed no allergic reactions to CP pollen extract.

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Implications:

Papaya flower pollen is identified as a potential inducer of respiratory allergies.
Common allergens exist between papaya pollen, fruit, and papain, explaining cross-reactivity.
This research highlights the need for awareness regarding CP pollen as an allergen.