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Mesalazine release from a pH dependent formulation: effects of omeprazole and lactulose co-administration
F N Hussain1, R A Ajjan, M Moustafa
1Department of Gastroenterology, Northern General Hospital, Sheffield.
Aims:
Delayed-release formulations of mesalazine often rely on the gastrointestinal luminal pH profile to deliver 5-aminosalicylic acid (5ASA) to the colon. The aim of this study was to examine the influence of luminal pH on mesalazine release.
Methods:
We studied the effect of co-administration of omeprazole and lactulose on the steady-state pharmacokinetics of Eudragit S-coated mesalazine in healthy volunteers.
Results:
No significant changes in urinary or faecal levels of 5ASA or its main metabolite, N-acetyl 5ASA, were apparent.
Conclusions:
This study suggests that co-administration of omeprazole and lactulose does not impair the release of delayed-release mesalazine.