Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intergroup Rhabdomyosarcoma Study: update for pathologists

S J Qualman1, C M Coffin, W A Newton

  • 1Department of Laboratory Medicine and IRSG Pathology Center, Children's Hospital and Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43205, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|December 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase III trial of short-course radiotherapy followed by CAPOXIRI versus CAPOX in locally advanced rectal cancer: the ENSEMBLE trial.

ESMO gastrointestinal oncology·2026
Same author

Clinical outcome after CyberKnife® radiosurgery re-irradiation for recurrent brain metastases.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2021
Same author

Distribution of ASIC4 transcripts in the adult wild-type mouse brain.

Neuroscience letters·2017
Same author

Isolation of a 2-Pyrone Compound as an Antioxidant from a Fungus and Its New Reaction Product with 1,1-Diphenyl-2-picrylhydrazyl Radical.

Bioscience, biotechnology, and biochemistry·2016
Same author

Neuropathic Pain Features in Patients with Bone Metastases.

Clinical oncology (Royal College of Radiologists (Great Britain))·2015
Same author

PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells.

Oncogene·2013
Same journal

Rhabdomyomatous Mesenchymal Hamartoma With Prominent Folliculosebaceous Hyperplasia in an Infant's Philtrum: A Case Report.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Heterotopic Salivary Gland in the Rectum Associated with Lumbosacral Lipomeningocele: A Dual Developmental Anomaly.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Assessing Normal Histologic Patterns in Perinatal Tissue: A Practical Guide.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Perinatal Autopsy Guidance for the General Pathologist.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

The Placenta: Identifying Normal.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Ancillary and Advanced Techniques for the Postmortem Examination.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
See all related articles

The new International Classification of Rhabdomyosarcoma (ICR) refines childhood rhabdomyosarcoma (RMS) diagnosis. Histopathology and molecular data from ICR help define prognostic categories and guide future therapeutic strategies.

Area of Science:

  • Pediatric Pathology
  • SarcOma Research
  • Cancer Classification

Background:

  • Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma.
  • The Intergroup Rhabdomyosarcoma Study Group (IRSG) has been pivotal in advancing RMS research and treatment.
  • Previous IRSG trials (I-IV) have led to the development of a new International Classification of Rhabdomyosarcoma (ICR).

Purpose of the Study:

  • To define emerging histopathologic categories of RMS according to the ICR.
  • To highlight the importance of correlative immunohistochemical and molecular studies in RMS diagnosis.
  • To provide practicing pathologists with updated diagnostic criteria for childhood RMS.

Main Methods:

  • Review of pathology cases from the Intergroup Rhabdomyosarcoma Study Group (IRSG).

Related Experiment Videos

  • Integration of histopathologic features with immunohistochemical and molecular data.
  • Analysis of emerging variants within the International Classification of Rhabdomyosarcoma (ICR).

    • Main Results:

    • The ICR introduces new morphologic concepts for RMS classification.
    • Emerging ICR variants correlate with distinct prognostic outcomes (e.g., favorable botryoid/spindle cell vs. unfavorable solid alveolar/anaplastic).
    • Specific fusion genes (t(1;13) and t(2;13)) are associated with particular RMS subtypes.

    Conclusions:

    • The ICR provides a refined framework for diagnosing childhood RMS.
    • Combining ICR histopathology with molecular findings is crucial for stratifying patients into prognostic and therapeutic subgroups.
    • Familiarity with the ICR and associated studies is essential for pathologists managing pediatric RMS.