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Ethylene glycol poisoning in a child treated with 4-methylpyrazole
Insights
4-methylpyrazole (4-MP) effectively treated a child with ethylene glycol (EG) poisoning, correcting acidosis and increasing EG half-life without adverse effects. This demonstrates 4-MP as a viable antidote for EG intoxication.
Area of Science:
- Toxicology
- Pharmacology
Background:
- Ethylene glycol (EG) poisoning is a life-threatening condition.
- 4-methylpyrazole (4-MP) is an alcohol dehydrogenase inhibitor investigated as a potential antidote for EG intoxication.
Observation:
- A 4-year-old child ingested a potentially lethal dose of EG.
- Treatment with 4-MP was initiated 7 hours post-ingestion.
Findings:
- Plasma 4-MP concentrations achieved therapeutic levels, inhibiting EG metabolism.
- Rapid correction of metabolic acidosis and increased EG half-life were observed.
- No adverse effects associated with 4-MP treatment were noted.
Implications:
- 4-methylpyrazole (4-MP) offers an effective alternative to hemodialysis in treating ethylene glycol (EG) poisoning.
- This case highlights the successful application of 4-MP in pediatric EG intoxication.
- 4-MP demonstrates significant potential as a life-saving antidote for ethylene glycol poisoning.
Objective:
The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child.
Method And Results:
4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concentrations were in the range of the values reported to block EG metabolism. The efficiency of 4-MP treatment was confirmed by the rapid correction of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed.
Conclusion:
This child ingested a potentially lethal dose of EG despite a high concentration of bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP without recourse to hemodialysis.