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Gastric juice as a dissolution medium: surface tension and pH
1University of Athens, Department of Pharmacy, Greece.
European Journal of Drug Metabolism and Pharmacokinetics
|September 2, 1998
Summary
Gastric juice has low surface tension, but refluxed bile salts do not solely cause this. Further research is needed to identify the cause for adjusting dissolution test media.
Area of Science:
- Gastroenterology
- Biochemistry
- Pharmacokinetics
Background:
- Gastric juice surface tension is crucial for drug dissolution.
- Refluxed bile salts are suspected to lower gastric surface tension.
Purpose of the Study:
- To investigate the relationship between gastric juice surface tension, bile salt concentration, and pH.
- To determine if bile salts are the primary factor in reducing gastric surface tension.
Main Methods:
- Aspiration of gastric juice from eight patients.
- Measurement of surface tension, bile salt concentration, and pH.
Main Results:
- Surface tension ranged from 35-45 mM/m.
- pH was typically 1-2.
- Bile salt concentrations were usually 0-1 mM.
- No significant correlations were found between the three parameters.
Conclusions:
- Refluxed bile salts alone do not account for the low surface tension of gastric juice.
- The source of reduced gastric surface tension requires further identification.
- Accurate dissolution testing necessitates media that mimics physiological gastric conditions.