Related Experiment Video
Updated: Jul 23, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Amiloride pharmacokinetics in rat
G Segre1, D Cerretani, G Bruni
1Istituto di Farmacologia, University of Siena, Italy.
Abstract:
The kinetics of amiloride was investigated in plasma, urine, faeces and tissues of rats after oral (10 mg/kg) and i.v. (10 mg/kg bolus and 35 microg/h for 4-days infusion) administration. Initially the experimental data were analyzed by a multiexponential model, then a compartmental model was developed to describe the drug kinetics in plasma, urine, faeces and tissues after the i.v. bolus and the oral administration simultaneously. Aim of the model was also to predict the drug kinetics in plasma and tissues of rats after continuous i.v. infusion. The results of the prediction and the discrepancies between prediction and observed data allowed a deeper insight into the pharmacokinetics of amiloride.
More Related Videos
Related Concept Videos
Time Course of Drug Effect
Determination of Michaelis Constant and Maximum Elimination Rate
These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Dosage Regimens: Partial Pharmacokinetic Parameters
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship

