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Triazolam-induced changes in alcoholic thought processes

H J Weingartner1, R Rawlings, D T George

  • 1Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-1250, USA. HerbW@NIH.GOV

Psychopharmacology
|September 2, 1998
PubMed
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This study found that Halcion (triazolam) equally impaired memory recall in alcoholics and normal volunteers. However, alcoholics showed more memory errors and generated less common semantic associations after Halcion administration.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychopharmacology

Background:

  • Benzodiazepines like Halcion (triazolam) are known to affect cognitive functions.
  • Detoxified alcoholics may exhibit altered cognitive responses to psychoactive substances.
  • Understanding these effects is crucial for managing cognitive impairments in vulnerable populations.

Purpose of the Study:

  • To compare the cognitive effects of Halcion (triazolam) on explicit memory and semantic knowledge access in normal volunteers and detoxified alcoholics.
  • To investigate potential qualitative differences in cognitive processing between these groups under drug challenge.

Main Methods:

  • A double-blind, placebo-controlled study involving ten normal volunteers and ten cognitively un-impaired detoxified alcoholics.

Related Experiment Videos

  • Administration of Halcion (triazolam) at a dose of 0.375 mg orally.
  • Assessment of explicit memory recall, intrusion errors, and semantic memory responses (response generation to stimuli).

    • Main Results:

    • Both groups showed equal impairment in explicit memory recall under Halcion.
    • Alcoholics exhibited significantly more intrusion errors (recalling unprompted information) compared to normal volunteers.
    • Following Halcion, alcoholics generated less common semantic associations, unlike their placebo condition responses.

    Conclusions:

    • Halcion (triazolam) administration reveals distinct cognitive processing differences in detoxified alcoholics compared to normal individuals.
    • The drug challenge simulates aspects of acute alcohol effects, highlighting qualitative memory and semantic access alterations in alcoholics.
    • These findings underscore the differential impact of psychoactive substances on cognitive functions in individuals with a history of alcoholism.