Related Experiment Videos
Age-related differences in the pancreatic beta-cell response to hyperglycemia after eccentric exercise
R K Krishnan1, J M Hernandez, D L Williamson
1Noll Physiological Research Center and the General Clinical Research Center, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
The American Journal of Physiology
|September 2, 1998
Summary
Eccentric exercise (ECC) impairs pancreatic beta-cell response in older adults, unlike in younger individuals. Age affects how the body handles glucose after strenuous activity, with older adults showing reduced insulin secretion.
Area of Science:
- Exercise Physiology
- Endocrinology
- Gerontology
Background:
- Eccentric exercise (ECC) is known to cause muscle damage and insulin resistance.
- Young individuals exhibit increased pancreatic beta-cell secretion following ECC.
- The impact of aging on pancreatic beta-cell response to glucose after ECC remains unclear.
Purpose of the Study:
- To investigate the age-related differences in pancreatic beta-cell response to glucose after eccentric exercise.
- To determine if older adults show a similar compensatory increase in beta-cell secretion as younger individuals post-ECC.
Main Methods:
- Hyperglycemic clamps were conducted on young (22 yrs) and older (66 yrs) healthy males.
- Measurements were taken during control (CONT) conditions and 48 hours after ECC.
- Insulin and C-peptide secretion, muscle soreness, and plasma creatine kinase were assessed.
Main Results:
- ECC induced muscle damage and elevated creatine kinase in both age groups.
- Young subjects showed increased first-phase C-peptide secretion post-ECC, but older subjects did not.
- Older individuals experienced repressed first-phase peak C-peptide concentrations and age-related differences in insulin/C-peptide clearance after ECC.
Conclusions:
- Older adults do not exhibit the compensatory increase in pancreatic beta-cell secretion seen in younger individuals after ECC.
- Increasing age appears to reduce the pancreatic beta-cell's responsiveness to the physiological stress of ECC.
- Abdominal adiposity correlated negatively with C-peptide response post-ECC in both phases.