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Effects of risperidone in overdose
1Children's Hospital of Philadelphia, PA, USA.
The American Journal of Emergency Medicine
|September 3, 1998
Summary
Risperidone overdose typically causes mild central nervous system and reversible cardiovascular effects. Most patients recover within 72 hours, but co-ingestions can lead to severe outcomes.
Area of Science:
- Toxicology
- Pharmacology
- Emergency Medicine
Background:
- Risperidone is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
- Overdose cases require understanding of its toxicological profile and clinical manifestations.
Purpose of the Study:
- To describe the clinical features and outcomes of risperidone overdose cases.
- To identify factors influencing toxicity and recovery in overdose patients.
Main Methods:
- Prospective, descriptive case series over 13 months.
- Data collected from a regional poison control center and emergency departments.
- Analysis of medical history, co-ingestants, clinical findings, and treatment outcomes.
Main Results:
- Thirty-one risperidone overdose cases were analyzed.
- Sole risperidone ingestion caused CNS, neuromuscular, and cardiovascular effects.
- Co-ingestions led to more severe symptoms, including one fatality.
- Most patients recovered within 72 hours.
Conclusions:
- Risperidone toxicity primarily presents with mild CNS and reversible neuromuscular/cardiovascular effects.
- Co-ingestions significantly increase the risk of severe outcomes.
- Prompt supportive care is crucial for managing risperidone overdose.