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Effects of risperidone in overdose

A A Acri1, F M Henretig

  • 1Children's Hospital of Philadelphia, PA, USA.

The American Journal of Emergency Medicine
|September 3, 1998
PubMed
Summary
This summary is machine-generated.

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Risperidone overdose typically causes mild central nervous system and reversible cardiovascular effects. Most patients recover within 72 hours, but co-ingestions can lead to severe outcomes.

Area of Science:

  • Toxicology
  • Pharmacology
  • Emergency Medicine

Background:

  • Risperidone is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
  • Overdose cases require understanding of its toxicological profile and clinical manifestations.

Purpose of the Study:

  • To describe the clinical features and outcomes of risperidone overdose cases.
  • To identify factors influencing toxicity and recovery in overdose patients.

Main Methods:

  • Prospective, descriptive case series over 13 months.
  • Data collected from a regional poison control center and emergency departments.
  • Analysis of medical history, co-ingestants, clinical findings, and treatment outcomes.

Main Results:

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  • Thirty-one risperidone overdose cases were analyzed.
  • Sole risperidone ingestion caused CNS, neuromuscular, and cardiovascular effects.
  • Co-ingestions led to more severe symptoms, including one fatality.
  • Most patients recovered within 72 hours.

Conclusions:

  • Risperidone toxicity primarily presents with mild CNS and reversible neuromuscular/cardiovascular effects.
  • Co-ingestions significantly increase the risk of severe outcomes.
  • Prompt supportive care is crucial for managing risperidone overdose.