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Warfarin-induced skin necrosis

T J Gelwix1, M S Beeson

  • 1Department of Emergency Medicine, Summa Health System, Akron, OH 44304, USA.

The American Journal of Emergency Medicine
|September 3, 1998
PubMed
Summary
This summary is machine-generated.

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Warfarin therapy can rarely cause skin necrosis, a condition that may resemble other disorders. This case highlights warfarin-induced skin necrosis in a patient presenting with breast and foot swelling and bruising.

Area of Science:

  • Cardiology
  • Dermatology
  • Pharmacology

Background:

  • Warfarin is a widely used anticoagulant.
  • Skin necrosis is a rare but serious adverse effect of warfarin therapy.
  • Early recognition is crucial for effective management.

Observation:

  • A 72-year-old woman presented with acute swelling and ecchymosis in her left breast and right foot.
  • The patient had recently undergone coronary artery bypass grafting.
  • Her symptoms began shortly after discharge on warfarin therapy.

Findings:

  • The clinical presentation mimicked other conditions, necessitating a thorough differential diagnosis.
  • Warfarin-induced skin necrosis is characterized by thrombosis of small venules and capillaries.

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  • Pathophysiology involves a transient hypercoagulable state due to rapid depletion of protein C.

    • Implications:

    • This case underscores the importance of considering warfarin-induced skin necrosis in patients on anticoagulation.
    • Awareness of this complication can lead to timely diagnosis and treatment, potentially preventing severe tissue damage.
    • Further research into risk factors and preventative strategies for warfarin-induced skin necrosis is warranted.