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Spindle epithelial tumour with thymus-like element (SETTLE): the predominantly monophasic variant
R Chetty1, S Goetsch, S Nayler
1Department of Pathology, University of Natal School of Medicine, Durban, South Africa.
Histopathology
|September 3, 1998
Summary
This study details two spindle epithelial tumour with thymus-like element (SETTLE) cases, predominantly spindle cell tumors. These findings aid in distinguishing SETTLE from similar thyroid pathologies.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Spindle epithelial tumour with thymus-like element (SETTLE) is a rare thyroid neoplasm.
- Understanding its diverse histological presentations is crucial for accurate diagnosis.
Observation:
- Two cases of SETTLE presented predominantly with spindle cell morphology.
- Unusual features included focal squamous epithelium, ductular structures, and stromal calcification.
- Immunohistochemistry revealed diffuse vimentin and cytokeratin expression in spindle cells.
Findings:
- SETTLE can exhibit a predominantly spindle cell pattern with minimal epithelial components.
- Stromal calcification is an identified feature in some SETTLE cases.
- Immunoreactivity for AE1/3, CAM5.2, and vimentin is characteristic of the spindle cells.
Implications:
- Accurate differentiation of SETTLE from mimics like synovial sarcoma is essential.
- Recognizing these spindle-predominant variants aids in appropriate patient management.
- Further research into SETTLE pathogenesis and classification is warranted.