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Published on: January 17, 2019
Massive lymphocytic infiltration of uterine leiomyomas associated with GnRH agonist treatment
V Bardsley1, P Cooper, D S Peat
1Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK.
Aims:
To report two unusual cases of massive lymphocytic infiltration of uterine leiomyomas, following GnRH agonist treatment. Previous reports have described a variety of alterations in leiomyoma histology following such therapy.
Methods And Results:
These cases were studied using haematoxylin and eosin stains, and immunohistochemistry for B and T-cell markers (CD20/CD79a and CD3/UCHL-1) was performed. Leiomyomas were heavily infiltrated predominantly by mature lymphocytes of T-cell phenotype. Associated myocyte degenerative changes were present.
Conclusions:
Massive lymphocytic infiltration of leiomyomas may occur as a result of GnRH agonist treatment, although the mechanism is unclear.
