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Related Experiment Videos

Iatrogenic gallstones: a ceftriaxone complication

D K Kearney1, D O'Donnell

  • 1Department of Diagnostic Radiology, Fremantle Hospital, Australia. fhrad@mail.wt.com.au

Australasian Radiology
|September 4, 1998
PubMed
Summary
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Gallstones causing biliary colic can form during Ceftriaxone therapy. These drug-induced gallstones may spontaneously dissolve after discontinuing the antibiotic.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Hepatology

Background:

  • Ceftriaxone is a common antibiotic used to treat various bacterial infections.
  • Gallstone formation (cholelithiasis) is a known potential adverse effect of certain medications.
  • Biliary colic is a common symptom associated with gallstones obstructing the bile ducts.

Observation:

  • A patient developed biliary colic attributed to gallstones.
  • The gallstones were observed to form during a course of Ceftriaxone treatment.
  • Symptoms of biliary colic resolved after the antibiotic therapy was stopped.

Findings:

  • Ceftriaxone therapy was associated with the formation of gallstones.
  • Cessation of Ceftriaxone therapy led to the dissolution of these drug-induced gallstones.

Related Experiment Videos

  • The case highlights a reversible cause of gallstone formation.

    • Implications:

    • This case suggests a potential mechanism for Ceftriaxone-induced cholelithiasis.
    • It underscores the importance of considering medication side effects in the differential diagnosis of gallstones.
    • Further research may elucidate the exact mechanism of Ceftriaxone on gallbladder motility and bile composition.