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[Effects of plasmapheresis and lasers on the state of urinary microflora in chronic pyelonephritis]
Abstract:
Bacteria isolated from the urine of 142 patients with chronic pyelonephritis (CPN) were examined for pathogenic properties of the strains (bacteriuria, hemolytic, proteolytic properties, urease, adhesive activity, antibiotic resistance, the ability to inactivate bactericidal activity of the serum) to control the effect of the treatment: antibiotics combined with plasmapheresis or antibiotics combined with laser radiation (intravascular, transcutaneous, or both). Combined application of intravascular and transcutaneous laser irradiation in multimodality treatment reduces the number of highly pathogenic strains as well as antibactericidal activity of the urine strains. It also promotes normalization of bacteriuria level. Plasmapheresis is inferior to laser radiation but ranks the second in efficacy of action on urinary microflora. Thus, use of efferent methods, especially transcutaneous plus intravascular laser radiation, plasmapheresis, in combined treatment of pyelonephritis decreases pathogenicity of urine strains and normalizes bacteriuria.
Insights
This study shows that combining antibiotics with laser therapy or plasmapheresis effectively reduces pathogenic bacteria in chronic pyelonephritis (CPN). Laser therapy, particularly intravascular and transcutaneous, proved most effective in controlling urinary tract infections.
Area of Science:
- Urology
- Microbiology
- Medical Physics
Background:
- Chronic pyelonephritis (CPN) involves persistent bacterial infection in the kidneys.
- Assessing pathogenic properties of urinary bacteria is crucial for effective treatment.
- Conventional antibiotic therapy may require adjunctive treatments for CPN.
Purpose of the Study:
- To evaluate the efficacy of antibiotics combined with plasmapheresis or laser radiation in treating CPN.
- To compare the impact of different efferent methods on the pathogenic properties of urinary bacteria.
Main Methods:
- Bacteria from 142 CPN patients were analyzed for virulence factors.
- Treatments included antibiotics with plasmapheresis or laser radiation (intravascular, transcutaneous, or both).
- Pathogenic properties, serum bactericidal activity, and bacteriuria levels were monitored.
Main Results:
- Combined intravascular and transcutaneous laser irradiation significantly reduced highly pathogenic strains and improved bacteriuria levels.
- Laser therapy also decreased the antibactericidal activity of urine strains.
- Plasmapheresis showed efficacy but was less effective than laser radiation.
Conclusions:
- Efferent methods, especially combined laser radiation, enhance antibiotic treatment for CPN.
- These combined therapies decrease bacterial pathogenicity and normalize bacteriuria.
- Laser radiation and plasmapheresis offer valuable adjunctive strategies for managing CPN.