Methicillin-sensitive variants in ageing broth cultures of methicillin-resistant Staphylococcus aureus

Methicillin-sensitive variants have been isolated from ageing broth cultures of the methicillin-resistant strain of Staphylococcus aureus NCTC 10442 and also from numerous other strains. There were wide variations and fluctuations in the incidence of sensitive variants from cultures incubated under uniform conditions.