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Related Experiment Videos

In vivo perfusion measurements in the human placenta using echo planar imaging at 0.5 T

P A Gowland1, S T Francis, K R Duncan

  • 1Magnetic Resonance Centre, Department of Physics, Obstetrics and Gynaecology, City Hospital, Nottingham, United Kingdom.

Magnetic Resonance in Medicine
|September 4, 1998
PubMed
Summary

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This study measured human placental perfusion using advanced MRI techniques. The findings suggest an optimized imaging sequence for accurate and efficient placental blood flow assessment in pregnancy.

Area of Science:

  • Medical Imaging
  • Physiology
  • Obstetrics

Background:

  • Accurate measurement of placental perfusion is crucial for monitoring fetal well-being.
  • Previous methods for in vivo placental perfusion assessment have limitations.

Purpose of the Study:

  • To present the first in vivo measurements of human placental perfusion from 20 weeks gestation to term.
  • To optimize magnetic resonance imaging (MRI) sequences for placental perfusion measurement.
  • To determine the optimal sequence parameters for signal-to-noise ratio and measurement time.

Main Methods:

  • Utilized a non-selective/selective inversion recovery echo-planar imaging sequence.
  • Acquired data with alternating selective and non-selective inversion pulses.
  • Collected 20 pairs of images at various inversion times (20-4510 ms) with a repetition time (TR) of 10 s.

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Main Results:

  • The average placental perfusion rate in normal pregnancies was 176 (±24) ml/100 mg/min.
  • Expected variability due to signal-to-noise ratio was calculated at 71%.
  • An optimized sequence with 8 repetitions at 10 geometrically spaced inversion times (TR=5s) yielded 38% pixel variability within 400s.

Conclusions:

  • The study provides a foundation for in vivo placental perfusion quantification using MRI.
  • An optimized sequence is proposed for efficient and reliable placental perfusion measurements.
  • The methodology can be adapted for perfusion studies in other anatomical regions.