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Segregation of transcription and replication sites into higher order domains
X Wei1, J Samarabandu, R S Devdhar
1Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Science (New York, N.Y.)
|September 4, 1998
Abstract:
Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.