Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vertebrate photoreceptor cell development and disease

E M Morrow1, T Furukawa, C L Cepko

  • 1Dept of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Trends in Cell Biology
|September 5, 1998
PubMed
Summary

Photoreceptors are crucial for vision and neuronal development. Understanding their development, including the role of the Crx transcription factor, is key to combating blindness-causing diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains.

Molecular psychiatry·2013
Same author

Retinal progenitor cells can produce restricted subsets of horizontal cells.

Proceedings of the National Academy of Sciences of the United States of America·2007
Same author

Characterization of mice with targeted deletion of glycine receptor alpha 2.

Molecular and cellular biology·2006
Same author

The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina.

Current biology : CB·2005
Same author

An analysis of the gene expression program of mammalian neural progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America·2004
Same author

Genomics approaches to photoreceptor development and disease.

Harvey lectures·2003

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Ophthalmology

Background:

  • Photoreceptors are vital for vertebrate neuronal differentiation.
  • Many human diseases causing blindness target photoreceptors.
  • Studying photoreceptor development is of significant interest.

Purpose of the Study:

  • To discuss the current understanding of photoreceptor development.
  • To highlight the role of the homeodomain transcription factor Crx.
  • To explore Crx's potential involvement in human vision diseases.

Main Methods:

  • Review of current literature on photoreceptor development.
  • Analysis of the function of the Crx transcription factor.
  • Examination of genetic and molecular pathways involved.

Related Experiment Videos

Main Results:

  • Photoreceptor differentiation is a complex process involving multiple genetic factors.
  • The homeodomain transcription factor Crx plays a significant role in photoreceptor development.
  • Crx is implicated in the pathogenesis of certain inherited retinal diseases.

Conclusions:

  • Understanding photoreceptor development is essential for treating vision disorders.
  • The transcription factor Crx is a key regulator in photoreceptor differentiation.
  • Further research into Crx may lead to novel therapeutic strategies for blindness.