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Kidney function changes in rats after single-dose administration of borocaptate sodium
1Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague.
Physiological Research
|January 1, 1997
Summary
Borocaptate sodium (BSH) administration in rats led to decreased kidney function, including reduced renal plasma flow and glomerular filtration rate. These changes may be linked to cardiovascular effects rather than direct kidney impact.
Area of Science:
- Nephrology
- Pharmacology
- Toxicology
Background:
- Borocaptate sodium (BSH) is a boron delivery compound used in neutron capture therapy.
- Understanding its effects on kidney function is crucial for patient safety.
Purpose of the Study:
- To investigate the impact of a single dose of BSH on rat kidney function.
- To determine the mechanisms behind observed renal changes.
Main Methods:
- Kidney function parameters including glomerular filtration rate (GFR), renal plasma flow rate, and urine flow rate (UFR) were measured in rats.
- Measurements were taken after intravenous BSH administration (25 mg/kg) under anesthesia.
- 14C-inulin clearance and 3H-p-aminohippuric acid clearance were used to assess GFR and renal plasma flow, respectively.
Main Results:
- A gradual decrease in renal plasma flow and GFR was observed following BSH injection.
- A consistent reduction in the filtration fraction was noted.
- These effects were accompanied by a temporary increase in urine flow rate.
Conclusions:
- BSH administration significantly alters kidney function in rats.
- Observed renal changes may be partly mediated by cardiovascular system disturbances.
- The role of BSH's dianionic sulfhydryl group in these effects warrants further investigation.