Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The decrease of serum leptin levels in oestrogen-treated male mice

J Nedvídková¹, M Haluzík, V Schreiber

¹Institute of Endocrinology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Physiological Research

|January 1, 1997

Summary

Estrogen administration significantly lowers serum leptin levels and body weight in male mice. This suggests a potential satiety factor counteracting low leptin, impacting weight regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessing the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin therapy with a continuous glucose monitor in adults with type 2 diabetes (COYOTE study): a randomised parallel study protocol.

BMJ open·2026

Same author

Risk Stratification and Coronary Optical Coherence Tomography Findings in Asymptomatic Patients With Type 1 Diabetes Mellitus.

Physiological research·2025

Same author

Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation.

Physiological research·2025

Same author

Novel predictors of preeclampsia and pregnancy complications: the impact of type 1 diabetes mellitus on maternal and fetal circulatory levels.

Physiological research·2025

Same author

Clinical practice guidelines for perioperative care in bariatric surgery 2023: Adapted ERAS (enhanced recovery after surgery) guidelines with consensual voting of the working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery….

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024

Same author

Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021

Area of Science:

Endocrinology
Metabolism
Neuroendocrinology

Background:

Leptin, an adipocyte hormone, regulates body weight homeostasis and energy balance.
Estrogens (oestradiol-benzoate) were previously shown to decrease body weight and influence the sympathetic system in male rats.
Estrogens also affect cAMP levels, activating protein kinase A and hormone-sensitive lipase.

Purpose of the Study:

To investigate the effect of estrogens on serum leptin levels in male mice.
To test the hypothesis that estrogen administration influences leptin levels.

Main Methods:

Chronic administration of oestradiol-benzoate to male mice.
Measurement of serum leptin levels.
Monitoring of body weight and food consumption.

Related Experiment Videos

Main Results:

Chronic oestradiol-benzoate administration significantly attenuated serum leptin levels.
The reduction in leptin levels was dependent on the duration of estrogen administration.
Simultaneously, a decrease in body weight was observed in the treated mice.
Food consumption was also affected, supporting the existence of a satiety factor.

Conclusions:

Estrogens can significantly influence serum leptin levels in male mice.
The mechanism may involve interaction with the cAMP signal transmission system, potentially at the genomic level.
The findings suggest a complex interplay between estrogens, leptin, and satiety in body weight regulation.