Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphomas in the immunocompromised patient

M D DeMario1, D N Liebowitz

  • 1Department of Medicine, University of Chicago, IL 60637, USA.

Seminars in Oncology
|September 5, 1998
PubMed
Summary

Lymphomas are common in acquired immunodeficiency syndrome (AIDS) patients, with varied treatment responses and poor prognoses. Research explores therapies for AIDS-related lymphomas and post-transplant lymphoproliferative disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation.

Bone marrow transplantation·2001
Same author

Efficient expression of foreign genes in human CD34(+) hematopoietic precursor cells using electroporation.

Gene therapy·2001
Same author

Nasopharyngeal carcinoma.

Lancet (London, England)·1999
Same author

A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days.

Cancer chemotherapy and pharmacology·1999
Same author

Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC.

Genes, chromosomes & cancer·1999
Same author

Costimulatory approaches to adoptive immunotherapy.

Current opinion in oncology·1998

Area of Science:

  • Oncology
  • Immunology
  • Infectious Diseases

Background:

  • Lymphoma frequently complicates immunosuppression, particularly in patients with acquired immunodeficiency syndrome (AIDS).
  • AIDS-related lymphomas encompass systemic, primary central nervous system (CNS), Hodgkin's disease, and primary effusion lymphoma subtypes.
  • Post-transplant lymphoproliferative disorders represent a spectrum of conditions following solid organ or bone marrow transplantation.

Purpose of the Study:

  • To review current understanding and therapeutic approaches for lymphomas in immunosuppressed individuals, focusing on AIDS and post-transplant patients.
  • To highlight the challenges and outcomes associated with different lymphoma types in these specific patient populations.

Main Methods:

  • Literature review of studies on AIDS-related lymphomas and post-transplant lymphoproliferative disorders.
  • Analysis of treatment regimens, response rates, and survival data for various lymphoma subtypes.
  • Examination of therapeutic strategies, including chemotherapy and radiotherapy.

Main Results:

  • Multiple treatment regimens exist for systemic AIDS-related lymphoma, but median survival remains under one year.
  • Radiotherapy is standard for primary CNS lymphoma in AIDS patients, with chemotherapy combinations showing potential improvement.
  • Prognosis for AIDS-related lymphomas is poor, with patients often succumbing to lymphoma or opportunistic infections.
  • No established standard therapy exists for post-transplant lymphoproliferative disorders.

Conclusions:

  • AIDS-related lymphomas present significant therapeutic challenges with limited survival benefits.
  • Further research is needed to establish effective and standardized treatments for post-transplant lymphoproliferative disorders.
  • Optimizing treatment strategies for these complex lymphomas is crucial for improving patient outcomes.

Related Experiment Videos