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Sequence variation of a hypervariable short tandem repeat at the D1S1656 locus

M V Lareu1, S Barral, A Salas

  • 1Institute of Legal Medicine, Faculty of Medicine, Santiago de Compostela, Spain.

International Journal of Legal Medicine
|September 5, 1998
PubMed
Summary

Researchers analyzed the D1S1656 short tandem repeat (STR), finding it highly polymorphic with over 0.89 heterozygosity. Its simple structure and small size make it valuable for forensic and genetic identification.

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Area of Science:

  • Forensic Genetics
  • Human Population Genetics
  • Molecular Biology

Background:

  • Short tandem repeats (STRs) are crucial genetic markers.
  • The D1S1656 locus is a compound hypervariable STR.
  • Understanding STR allele structure and variation is key for genetic analysis.

Purpose of the Study:

  • To sequence and characterize alleles at the D1S1656 locus.
  • To determine the polymorphic nature and heterozygosity of this STR.
  • To evaluate its utility in forensic and genetic applications.

Main Methods:

  • Sequencing of 45 selected alleles at the D1S1656 locus.
  • Analysis of STR repeat structure, including compound repeats and variations.
  • Population data analysis to calculate heterozygosity.

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Main Results:

  • Identified 13 different alleles based on total repeat numbers.
  • Characterized the compound hypervariable nature of the STR, with a basic sequence structure.
  • Observed intermediate alleles (a.3) attributed to a specific repeat deletion.
  • Demonstrated high polymorphism with a heterozygosity exceeding 0.89.

Conclusions:

  • The D1S1656 STR is highly polymorphic and exhibits significant heterozygosity.
  • Its simple structure and small amplicon size (129-168 bp) are advantageous.
  • This STR is a valuable DNA polymorphism for forensic science and genetic studies.