Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systematic evaluation of cellular radiosensitivity parameters

R A Roth, S C Sharma, R Katz

    Physics in Medicine and Biology
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Identification of AKT-regulated genes in inducible MERAkt cells.

    Physiological genomics·2002
    Same author

    Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents.

    Toxicology·2001
    Same author

    Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure.

    American journal of physiology. Gastrointestinal and liver physiology·2001
    Same author

    Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.

    The Journal of biological chemistry·2001
    Same author

    Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

    Biochemical and biophysical research communications·2001
    Same author

    Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide.

    Toxicology and applied pharmacology·2001
    Same journal

    Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

    Physics in medicine and biology·2026
    Same journal

    Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

    Physics in medicine and biology·2026
    Same journal

    Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

    Physics in medicine and biology·2026
    Same journal

    Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

    Physics in medicine and biology·2026
    Same journal

    Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

    Physics in medicine and biology·2026
    Same journal

    Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

    Physics in medicine and biology·2026
    See all related articles

    Cellular radiosensitivity parameters were evaluated using a nonlinear computer model. This research offers guidance for optimizing experiments to determine these parameters from high-energy radiation bombardments.

    Area of Science:

    • Radiation biology
    • Biophysics
    • Computational modeling

    Background:

    • The track structure theory by Katz and colleagues provides a framework for understanding cellular responses to radiation.
    • Accurate determination of cellular radiosensitivity parameters is crucial for predicting biological effects of radiation.
    • Previous methods for parameter evaluation may lack efficiency or require specific experimental conditions.

    Purpose of the Study:

    • To evaluate cellular radiosensitivity parameters within the framework of Katz's track structure theory.
    • To develop and apply a computational approach for efficient parameter determination.
    • To provide recommendations for experimental design in high LET radiation studies.

    Main Methods:

    • Utilized a sum of squares minimizing computer program designed for nonlinear models.

    Related Experiment Videos

  • Applied the program to evaluate cellular radiosensitivity parameters from existing data or simulations.
  • Focused on data derived from track-segment bombardments of high Linear Energy Transfer (LET) radiations.

    • Main Results:

    • Successfully evaluated key cellular radiosensitivity parameters using the developed computational method.
    • Demonstrated the feasibility of determining these parameters from track-segment data.
    • Identified specific experimental design considerations for efficient parameter measurement.

    Conclusions:

    • The computational approach provides an effective means to determine radiosensitivity parameters.
    • Optimized experimental designs can enhance the accuracy and efficiency of parameter determination.
    • This work contributes to a better understanding of radiation effects at the cellular level through improved parameterization of the track structure theory.