Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain
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Updated: Oct 28, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
R Bunzel1, I Blümcke, S Cichon
1Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111, Bonn, Germany.
Abstract:
We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic.
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