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Related Experiment Videos

Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats

E H Kwok1, N J Dun

  • 1Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, P.O. Box 70577, Johnson, TN 37614, USA.

Brain Research
|September 5, 1998
PubMed
Summary
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New opioid peptides, endomorphin 1 and 2, lower heart rate and blood pressure in rats. These effects are mediated by the vagal nerve and may involve vasodilation.

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroscience

Background:

  • Endomorphins are novel endogenous opioid peptides.
  • Opioid peptides can influence cardiovascular function.

Purpose of the Study:

  • To investigate the cardiovascular effects of endomorphin 1 and 2 in rats.
  • To elucidate the mechanisms underlying these effects.

Main Methods:

  • Intravenous administration of endomorphin 1 and 2 to urethane-anesthetized rats.
  • Assessment of heart rate (HR) and mean arterial pressure (MAP).
  • Administration of antagonists (naloxone, atropine) and vagotomy.

Main Results:

  • Endomorphin 1 and 2 caused dose-dependent decreases in HR and MAP.

Related Experiment Videos

  • Bradycardia and hypotension were antagonized by naloxone.
  • Atropine and vagotomy significantly reduced the bradycardic effect and attenuated hypotension.

    • Conclusions:

    • Systemic endomorphins induce bradycardia and hypotension in rats.
    • The bradycardia is primarily mediated by vagal afferent activation.
    • Hypotension may result from reduced cardiac output and/or vasodilation.