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Related Experiment Videos

Asymmetric cell division: lessons from flies and worms

B Lu1, L Y Jan, Y N Jan

  • 1Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143-0725, USA.

Current Opinion in Genetics & Development
|September 8, 1998
PubMed
Summary

Asymmetric cell division mechanisms in model organisms like Drosophila and C. elegans involve cortical polarity molecules and the cytoskeleton. Wnt and Frizzled signaling pathways highlight conserved mechanisms for cell polarity and fate determination.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Genetics

Background:

  • Asymmetric cell division is crucial for development.
  • Model organisms like Drosophila and Caenorhabditis elegans offer insights into these processes.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing asymmetric cell division.
  • To understand the role of cortical polarity and signaling pathways in cell fate determination.

Main Methods:

  • Genetic analysis in Drosophila and C. elegans.
  • Studies on cortically localized polarity organizing molecules.
  • Investigation of the actin cytoskeleton's role.
  • Analysis of Wnt and Frizzled signaling pathways.

Main Results:

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  • Cortical polarity molecules, adapter proteins, and the actin cytoskeleton are key to unequal segregation of cell-fate determinants.
  • Spindle orientation is precisely controlled during asymmetric division.
  • Wnt signaling in C. elegans and Frizzled signaling in Drosophila modulate cellular polarity.

Conclusions:

  • Conserved mechanisms exist for regulating asymmetric cell division and cellular polarity across different species.
  • These findings advance our understanding of developmental processes and cell fate control.