Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specificity in signaling pathways: assembly into multimolecular signaling complexes

S Tsunoda1, J Sierralta, C S Zuker

  • 1Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093-0649, USA.

Current Opinion in Genetics & Development
|September 8, 1998
PubMed
Summary

Scaffold proteins organize signaling molecules into specific cellular pathways. This organization ensures precise and selective cell signaling, crucial for cellular function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal changes in life-space mobility and the factors influencing it among chronic community-dwelling post-stroke patients.

Disability and rehabilitation·2021
Same author

Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling.

Die Pharmazie·2019
Same author

Generation of a sensitive TNFR2-specific murine assays system.

Die Pharmazie·2016
Same author

Gastrointestinal: Ultrasound-guided iatrogenic hydrothorax to permit drainage of a postoperative left subdiaphragmatic abscess.

Journal of gastroenterology and hepatology·2016
Same author

High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

Wavelength-selective light-triggered strand exchange reaction.

Organic & biomolecular chemistry·2016

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular signal transduction pathways require precise organization of signaling molecules.
  • Ensuring specificity and selectivity in signaling is a critical cellular challenge.
  • The spatial arrangement of signaling components is key to pathway fidelity.

Purpose of the Study:

  • To investigate the role of scaffold proteins in organizing cellular signaling pathways.
  • To understand how molecular architecture ensures signaling specificity.
  • To explore the formation of signaling ultramicrodomains.

Main Methods:

  • Analysis of protein-protein interactions.
  • Cellular imaging techniques.
  • Biochemical assays for signal transduction.

Related Experiment Videos

Main Results:

  • Scaffold proteins act as organizing centers for signaling complexes.
  • Defined architectural complexes enhance signaling specificity.
  • Formation of ultramicrodomains facilitates selective signal propagation.

Conclusions:

  • Scaffold proteins are essential for the precise assembly of signal transduction complexes.
  • Architecturally defined signaling complexes are a fundamental cellular strategy.
  • The organization of signaling molecules by scaffolds ensures cellular responsiveness and accuracy.