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Related Experiment Videos

Somitogenesis: segmenting a vertebrate

M J McGrew1, O Pourquié

  • 1Laboratoire de Génétique et de Physiologie du Développement (LGPD). CNRS-INSERM-Université de la méditerranée-AP de Marseille, France. mcgrew@ibdm.univ-mrs.fr

Current Opinion in Genetics & Development
|September 8, 1998
PubMed
Summary
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Vertebrate segmentation relies on coordinated mesodermal cell behavior. The Notch-Delta pathway and a molecular clock in the presomitic mesoderm are key to somite formation, suggesting conserved genetic mechanisms.

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Vertebrate body segmentation into somites requires precise mesodermal cell coordination.
  • Understanding conserved genetic mechanisms between Drosophila and vertebrates is crucial for segmentation research.

Purpose of the Study:

  • To investigate the genetic underpinnings of vertebrate somite formation.
  • To explore the role of conserved signaling pathways and molecular clocks in this process.

Main Methods:

  • Genetic studies in mouse models.
  • Analysis of the Notch-Delta signaling pathway.
  • Investigation of molecular clock mechanisms in presomitic mesoderm.

Main Results:

Related Experiment Videos

  • The Notch-Delta signaling pathway plays a significant role in mouse somite formation.
  • Evidence suggests a 'molecular clock' operates within the presomitic mesoderm.
  • Conservation of segmentation mechanisms between invertebrates and vertebrates is indicated.

    • Conclusions:

    • The Notch-Delta pathway is a critical regulator of vertebrate segmentation.
    • A molecular clock mechanism likely governs the temporal patterning of somite formation.
    • These findings highlight conserved genetic principles in body plan development across species.