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Related Experiment Videos

Antibody engineering

W Dall'Acqua1, P Carter

  • 1Department of Molecular Oncology, Genentech Incorporated, South San Francisco, CA 94080, USA.

Current Opinion in Structural Biology
|September 8, 1998
PubMed
Summary
This summary is machine-generated.

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New tools enable rapid large-scale mutational analysis of antibodies, advancing protein engineering. Ribosome display technology offers advantages for modifying antibody function compared to phage display.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Protein Engineering

Background:

  • Understanding the relationship between protein structure and function is crucial in antibody engineering.
  • Traditional methods for analyzing protein mutations can be time-consuming and limited in scale.

Purpose of the Study:

  • To highlight recent advancements in tools for studying protein structure-function relationships.
  • To introduce novel techniques for large-scale antibody analysis and engineering.

Main Methods:

  • Utilizing in vitro transcription and translation for rapid, large-scale mutational analysis of antibodies.
  • Employing ribosome display as an evolving technology for antibody engineering.

Main Results:

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  • In vitro transcription and translation now permit very rapid, large-scale mutational analysis of antibodies.
  • Ribosome display presents potential advantages over existing methods like phage display for antibody engineering.

    • Conclusions:

    • New tools are significantly accelerating the pace of discovery in antibody engineering.
    • Ribosome display is a promising technology for future antibody functional modification and development.