Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functionalization of designed folded polypeptides

L Baltzer1

  • 1Department of Chemistry, Göteborg University, Sweden, Lars.Baltzer@oc.chalmers.se

Current Opinion in Structural Biology
|September 8, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fungicidal activity of human lactoferrin-derived peptides based on the antimicrobial αβ region.

International journal of antimicrobial agents·2010
Same author

Structure-microbicidal activity relationship of synthetic fragments derived from the antibacterial alpha-helix of human lactoferrin.

Antimicrobial agents and chemotherapy·2009
Same author

Synthetic de novo designed polypeptides for control of nanoparticle assembly and biosensing.

Biochemical Society transactions·2007
Same author

Alpha-helix-inducing dimerization of synthetic polypeptide scaffolds on gold.

Langmuir : the ACS journal of surfaces and colloids·2005
Same author

Anti-inflammatory activities of human lactoferrin in acute dextran sulphate-induced colitis in mice.

Scandinavian journal of immunology·2003
Same author

De novo design of proteins--what are the rules?

Chemical reviews·2001
Same journal

Tomogram exploration through template matching and deep learning.

Current opinion in structural biology·2026
Same journal

A comparative review of cryo-electron ptychography: Biological applications and future perspectives.

Current opinion in structural biology·2026
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
See all related articles

Recent advances in folded polypeptide design have yielded novel catalysts and metal-binding peptides. Functionalization techniques further expand possibilities for protein engineering and understanding complex biological functions.

Area of Science:

  • Biochemistry
  • Protein Engineering
  • Synthetic Biology

Background:

  • Folded polypeptides are crucial biomolecules with diverse functions.
  • Designing novel folded polypeptides is essential for advancing biotechnology and medicine.
  • Existing methods for polypeptide synthesis and functionalization have limitations.

Purpose of the Study:

  • To review recent advancements in the design of folded polypeptides.
  • To highlight the development of new catalysts, metal-binding peptides, and folded glycopeptides.
  • To discuss the implications of postsynthetic and post-translational functionalization for protein engineering.

Main Methods:

  • Literature review of recent research in folded polypeptide design.
  • Analysis of techniques for postsynthetic and post-translational functionalization.

Related Experiment Videos

  • Examination of studies demonstrating function in complex polypeptide sites.

    • Main Results:

    • Successful design of folded polypeptides leading to new catalysts.
    • Creation of peptides capable of binding metal ions, hemes, and cofactors.
    • Development of folded glycopeptides with potential therapeutic applications.
    • Advancements in postsynthetic and post-translational functionalization techniques.

    Conclusions:

    • Recent progress in folded polypeptide design has significantly expanded the repertoire of accessible motifs.
    • Functionalization techniques offer new avenues for creating proteins with novel properties.
    • Understanding protein structure and function in complex sites is crucial for future protein engineering endeavors.