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Nephrotic syndrome in indian children

R N Srivastava, G Mayekar, R Anand

    Archives of Disease in Childhood
    |August 1, 1975
    PubMed
    Summary

    This study on childhood nephrotic syndrome in India found primary kidney disease in 96% of cases, predominantly in boys. Minimal lesions were common, and corticosteroid treatment success was linked to mild histological changes.

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    Area of Science:

    • Pediatric Nephrology
    • Clinical Pathology
    • Renal Histology

    Background:

    • Nephrotic syndrome is a significant kidney disorder in children.
    • Understanding the clinicopathological patterns in diverse populations is crucial.

    Purpose of the Study:

    • To investigate the clinicopathological features of nephrotic syndrome in Indian children.
    • To correlate histological findings with clinical presentation and treatment response.

    Main Methods:

    • A clinicopathological study of 206 Indian children diagnosed with nephrotic syndrome.
    • Renal biopsies were analyzed for histological abnormalities.
    • Correlation of biopsy findings with age of onset and response to corticosteroid therapy.

    Main Results:

    • A primary renal cause was identified in 96% of cases, with a male predominance (77%).
    • Minimal change disease was the most common finding (77%), often diagnosed years after symptom onset.
    • Significant histological abnormalities were more frequent with later onset and associated with nephritic manifestations.
    • Corticosteroid therapy was effective primarily in patients with minimal or mild histological changes.

    Conclusions:

    • The pattern of idiopathic nephrotic syndrome in Indian children mirrors that observed in Western populations.
    • Early diagnosis and histological assessment are important for predicting treatment outcomes in pediatric nephrotic syndrome.

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