Related Experiment Videos
Photoaffinity labeling of PKC isozymes by phorbol ester derivatives
K Uotsu1, M Sodeoka, M Shibasaki
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
Bioorganic & Medicinal Chemistry
|September 8, 1998
Abstract:
Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluorodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by both the probes resulted in specific cross-linking.