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Related Experiment Videos

Reversible neuropathy in chronic renal failure

A Roy1, J Kalita, N Gayathri

  • 1Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Nephron
|September 8, 1998
PubMed
Summary

Chronic renal failure can cause reversible motor neuropathy. A case study shows a patient with kidney failure experienced rapid motor nerve damage that improved with treatment.

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Area of Science:

  • Neurology
  • Nephrology
  • Internal Medicine

Background:

  • Chronic renal failure (CRF) is often linked to distal symmetrical axonal neuropathy.
  • Benign prostatic hyperplasia (BPH) can lead to CRF.

Observation:

  • A 50-year-old man with CRF secondary to BPH presented with fever and acute, pure motor neuropathy.
  • Nerve conduction studies revealed slow nerve conduction velocity and delayed F response, indicating demyelinating neuropathy.
  • Sural nerve biopsy confirmed demyelination and axonal damage.

Findings:

  • The patient showed significant improvement after intermittent catheterization and a brief course of norfloxacin.
  • This suggests a potential link between urinary tract issues, renal failure, and reversible motor neuropathy.

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Implications:

  • Renal failure may be associated with treatable motor neuropathies.
  • Early diagnosis and management of underlying causes like BPH are crucial.
  • This case highlights the importance of considering neurological complications in patients with CRF.