Metabolism of superoxide dismutase during the adynamic ileus of endotoxemia

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J J Cullen1, K S Ephgrave, L L Hemann

  • 1Department of Surgery and Internal Medicine, University of Iowa College of Medicine and VAMC, Iowa City, Iowa, USA.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|December 9, 1998
PubMed
Abstract

No abstract available in PubMed .

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Electron Transport Chain: Complex III and IV01:43

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During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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