Gonadotropin secretion in patients with gonadal dysgenesis

Plasma FSH and LH levels were investigated by the radioimmunological method of Burr et al. [1] in 35 patients with gonadal dysgenesis. In addition ten healthy, normally menstruating women were examined as controls. Plasma FSH levels were significantly elevated in the patients with gonadal dysgenesis, while LH concentration disclosed no characteristic alteration. There was no specific correlation between the plasma FSH and LH levels. The data obtained add further support to the idea that gonadotropin synthesis and release may be differentially affected by the gonadal steroids.