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Disseminated papular acantholytic dyskeratosis

M Ciupinska1, K Kalbarczyk, S Jablonska

  • 1Warsaw Municipal Dermatological Hospital, Poland.

Journal of the European Academy of Dermatology and Venereology : JEADV
|September 10, 1998
PubMed
Summary

Two elderly women presented with atypical papular eruption, featuring epidermal clefts, dyskeratosis, and acantholysis. These cases highlight the heterogeneous nature of papular acantholytic dyskeratosis, challenging classification due to varied clinical courses.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Transient disseminated papular eruption can present atypically in elderly individuals.
  • Distinguishing between various acantholytic and dyskeratotic dermatoses is crucial for accurate diagnosis and management.

Observation:

  • Two elderly female patients exhibited clinically atypical transient disseminated papular eruption.
  • Histopathological examination revealed suprabasal epidermal clefts with dyskeratosis and acantholysis.
  • The clinical presentation did not align with classic Darier's disease, Hailey's disease, or Grover's acantholysis.

Findings:

  • Despite clinical similarities, the two cases demonstrated distinct clinical courses and outcomes.
  • Histological findings of overlapping dyskeratosis and acantholysis varied between specimens.

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  • One patient with transient lesions showed more pronounced dyskeratosis compared to the patient with relapsing lesions over a 4-year period.

    • Implications:

    • These cases underscore the heterogeneity within the group of papular acantholytic dyskeratoses.
    • The findings suggest that some atypical presentations may defy easy classification into established disease categories.
    • Further research is needed to better understand the spectrum and classification of papular acantholytic dyskeratoses.