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Apoptosis: a role in skin aging?

A R Haake1, I Roublevskaia, M Cooklis

  • 1Department of Dermatology, University of Rochester School of Medicine & Dentistry, New York 14642, USA.

The Journal of Investigative Dermatology. Symposium Proceedings
|September 10, 1998
PubMed
Summary

Aging involves a decline in homeostasis and adaptive responses. This study explores how apoptosis, or programmed cell death, may be dysregulated in aging skin, contributing to intrinsic and photoaging.

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Area of Science:

  • Cellular Biology
  • Dermatology
  • Gerontology

Background:

  • Aging is characterized by a decline in homeostasis and adaptive responses to stress.
  • Apoptosis (programmed cell death) is a critical homeostatic mechanism and stress response.
  • Dysregulation of apoptosis may play a role in the aging process.

Purpose of the Study:

  • To introduce apoptosis, its regulation, and its role in epidermal homeostasis.
  • To investigate the contribution of apoptosis to skin aging.
  • To examine evidence of apoptotic dysregulation in aging.

Main Methods:

  • Review of prevailing theories on aging.
  • Introduction to apoptosis and its regulation in keratinocytes.
  • Discussion of evidence for apoptotic dysregulation in non-skin systems.

Main Results:

  • Apoptosis is crucial for epidermal homeostasis and keratinocyte differentiation.
  • Evidence suggests apoptotic dysregulation occurs during aging in various systems.
  • Decreased apoptotic efficiency may contribute to intrinsic and extrinsic skin aging.

Conclusions:

  • Apoptosis is a key cellular process potentially affected by aging.
  • Dysregulation of apoptosis may underlie age-related skin changes.
  • Further research is needed to confirm the role of apoptosis in skin aging.

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