Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging versus photoaging: postulated mechanisms and effectors

M Yaar1, B A Gilchrest

  • 1Boston University School of Medicine, Department of Dermatology, Massachusetts 02118-2394, USA.

The Journal of Investigative Dermatology. Symposium Proceedings
|September 10, 1998
PubMed
Summary

Intrinsic aging and photoaging differ significantly, impacting cellular signaling, gene expression, and the tumor suppressor gene p53. Understanding these differences is crucial for aging research and interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Barbara A. Gilchrest.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Age-associated decreases in human DNA repair capacity: Implications for the skin.

Age·2013
Same author

Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy.

Clinical and experimental dermatology·2012
Same author

Chronologic and actinically induced aging in human facial skin.

The Journal of investigative dermatology·2010
Same author

Keratin 16 expression in epidermal melanocytes.

The British journal of dermatology·2009
Same author

Cellular mechanisms regulating human melanogenesis.

Cellular and molecular life sciences : CMLS·2009

Area of Science:

  • Dermatology
  • Cell Biology
  • Genetics

Background:

  • Intrinsic aging and photoaging are distinct biological processes affecting skin.
  • Cellular senescence involves changes in gene expression and signaling pathways.
  • The tumor suppressor gene p53 plays a critical role in cellular responses to damage.

Purpose of the Study:

  • To review and compare intrinsic aging and photoaging.
  • To discuss model systems used in aging research.
  • To elucidate cellular and genetic differences between intrinsic and photoaging.

Main Methods:

  • Literature review of aging and photoaging studies.
  • Discussion of cellular senescence mechanisms.
  • Analysis of genetic factors, including p53 function.

Related Experiment Videos

Main Results:

  • Age-associated decrements in receptor/ligand signaling identified.
  • Changes in nuclear transcription factor expression during senescence described.
  • Role of telomere shortening and oxidative damage in aging explained.

Conclusions:

  • Intrinsic aging and photoaging exhibit distinct cellular and genetic profiles.
  • The tumor suppressor gene p53 is a key differentiator at the cellular level.
  • Further research into these differences can inform anti-aging strategies.