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Dopamine D2 receptors mediate glomerular hyperfiltration due to amino acids
1Department of Pharmacology, University of Tübingen, Germany.
The Journal of Pharmacology and Experimental Therapeutics
|September 11, 1998
Summary
Dopamine D2 receptors help regulate kidney function, specifically the glomerular filtration rate (GFR). Activating these receptors mimics the GFR increase seen after an amino acid load in rats.
Area of Science:
- Nephrology
- Pharmacology
- Physiology
Background:
- Renal dopamine's role in glomerular filtration rate (GFR) regulation is suggested.
- Dopamine D2 receptor inhibition blocks amino acid-induced renal hyperfiltration.
Purpose of the Study:
- To investigate if pharmacological activation of D2-like receptors mimics amino acid-induced hyperfiltration.
- To determine the involvement of central and peripheral D2 receptors in this response.
Main Methods:
- Administered quinpirole (D2-like receptor agonist) to anesthetized rats.
- Utilized D2 receptor antagonists (S(-)-sulpiride and domperidone) to block receptor activity.
- Measured changes in GFR and urinary dopamine excretion.
Main Results:
- Quinpirole increased GFR by 20%, similar to amino acid infusion.
- S(-)-sulpiride abolished the hyperfiltration response to both quinpirole and amino acids.
- Domperidone partially inhibited the hyperfiltration response.
- Urinary dopamine increased with amino acid load regardless of GFR changes.
Conclusions:
- Dopamine D2 receptors contribute to amino acid-induced hyperfiltration in rats.
- Both central and peripheral D2 receptors appear to be involved.
- Urinary dopamine excretion does not seem to play a direct role in this renal hemodynamic response.