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FGF-mediated mesoderm induction involves the Src-family kinase Laloo

D C Weinstein1, J Marden, F Carnevali

  • 1Department of Molecular Vertebrate Embryology, The Rockefeller University, New York, New York 10021, USA.

Nature
|September 11, 1998
PubMed
Summary

Scientists discovered a new Src-related kinase, laloo, crucial for mesoderm induction during Xenopus embryogenesis. Laloo

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signaling

Background:

  • Embryonic development relies on inductive signals to establish the body plan.
  • In Xenopus laevis, mesoderm induction is mediated by factors from the vegetal pole, involving TGF-beta and FGF signaling pathways.

Purpose of the Study:

  • To identify and characterize novel participants in the signal transduction cascade of mesoderm induction.
  • To investigate the role of a Src-related gene family member in vertebrate embryogenesis.

Main Methods:

  • Overexpression of laloo in Xenopus embryos.
  • Analysis of mesoderm induction in Xenopus ectodermal explants.
  • Utilizing dominant-inhibitory mutants to block signaling pathways.

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Main Results:

  • Overexpression of laloo led to ectopic posterior structures, including axial tissue.
  • Laloo induced mesoderm in ectodermal explants, a process inhibited by disrupting FGF signaling.
  • A dominant-inhibitory Laloo mutant blocked FGF-induced mesoderm induction and caused posterior truncations.

Conclusions:

  • Laloo is a novel Src-related kinase involved in vertebrate mesoderm induction.
  • This study provides the first evidence linking Src-related kinases to mesoderm induction during vertebrate development.