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Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary
R M Santos1, J F Tanguay, J J Crowley
1Duke University Medical Center, Durham, North Carolina 27710, USA.
The American Journal of Cardiology
|September 11, 1998
Abstract:
We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.