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Miniaturization of analytical systems

L J Kricka1

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA. larry_kricka@path1a.med.upenn.edu

Clinical Chemistry
|September 11, 1998
PubMed
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Miniaturization is shrinking clinical diagnostic instruments using new technologies like micromachining. These micro- and nanoscale devices offer faster, cheaper analyses and support pharmaceutical drug discovery.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Miniaturization is a significant trend in clinical diagnostics instrumentation.
  • Emerging technologies like micromachining and molecular self-assembly enable further size reduction of analytical devices.
  • Analytical techniques such as mass spectrometry and electrophoresis are being integrated onto microchips.

Purpose of the Study:

  • To explore the advancements in miniaturizing diagnostic analyzers.
  • To highlight the benefits driving the trend towards micro- and nanoscale diagnostic devices.
  • To discuss the potential impact on pharmaceutical drug discovery.

Main Methods:

  • Implementation of analytical techniques on microchips made from silicon, glass, or plastic.

Related Experiment Videos

  • Leveraging micromachining and molecular self-assembly for device fabrication.
  • Development of micro- to nanometer dimensioned devices with submicroliter volumes.

    • Main Results:

    • Successful integration of various analytical techniques onto microchips.
    • Development of diagnostic devices with micro- to nanometer dimensions and submicroliter volumes.
    • Demonstration of feasibility for massively parallel drug discovery assays.

    Conclusions:

    • Continued progress in miniaturization promises faster, more cost-effective, and convenient analyses.
    • Addressing user interface and sample volume limitations is crucial for widespread adoption.
    • The field is rapidly evolving, with near-future product releases anticipated.