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Primary cutaneous aspergillosis: our experience in 10 years
A Chakrabarti1, V Gupta, G Biswas
1Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
The Journal of Infection
|November 20, 1998
Summary
Primary cutaneous aspergillosis primarily affects immunocompromised adults, often those with burn wounds. Surgical debridement and antifungal treatment improve outcomes for most patients.
Area of Science:
- Dermatology
- Infectious Diseases
- Mycology
Background:
- Primary cutaneous aspergillosis is a rare fungal infection.
- This study reviews cases diagnosed between 1987 and 1996.
Observation:
- Nine adult patients were diagnosed with primary cutaneous aspergillosis.
- Seven patients were immunocompromised, with six having burn wounds and one a renal transplant recipient.
- Aspergillus flavus was the most common species identified.
Findings:
- Mortality was high in patients with extensive burn surface area (>70%).
- Most patients responded well to surgical debridement and/or oral itraconazole.
- Aspergillus flavus and Aspergillus fumigatus were the main causative agents.
Implications:
- Early diagnosis and aggressive treatment, including surgical debridement, are crucial for managing primary cutaneous aspergillosis.
- Identifying risk factors like immunocompromised status and burn wounds aids in patient management.
- Further research into effective antifungal strategies for this condition is warranted.