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The effect of sequential injuries on splanchnic perfusion and eicosanoid release
J L Iglesias1, R H Turnage, Y Meng
1Departments of Surgery, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, Texas, 75235-9031, USA.
The Journal of Surgical Research
|September 12, 1998
Summary
Sequential burn injury followed by sepsis surprisingly protects against severe splanchnic hypoperfusion. This protective effect occurs despite reduced intestinal PGI2 release, suggesting complex injury interactions.
Area of Science:
- Physiology
- Sepsis Research
- Trauma Studies
Background:
- Intraabdominal sepsis causes severe splanchnic hypoperfusion and reduced intestinal PGI2.
- The impact of combined burn injury and sepsis on splanchnic circulation is not well understood.
Purpose of the Study:
- To investigate if sequential burn injury and intraabdominal sepsis lead to greater splanchnic hypoperfusion and reduced intestinal PGI2 release compared to individual injuries.
- To determine the protective role of burn injury against sepsis-induced splanchnic hypoperfusion.
Main Methods:
- Rats were subjected to burn injury (BURN), cecal ligation and puncture (CLP), or both (BURN + CLP).
- Superior mesenteric artery (SMA) blood flow was measured using Doppler flowmetry.
- Splanchnic eicosanoid release (PGI2, TxA2, PGE2) was analyzed in mesenteric venous effluent.
Main Results:
- CLP alone caused an 80% reduction in splanchnic blood flow.
- BURN + CLP resulted in only a modest reduction in splanchnic blood flow, significantly higher than CLP alone.
- Intestinal PGI2 release decreased by 60% in CLP and BURN + CLP groups compared to controls.
Conclusions:
- Moderate burn injury attenuates severe splanchnic hypoperfusion caused by intraabdominal sepsis.
- This protective effect occurs despite reduced splanchnic PGI2 release, indicating complex compensatory mechanisms.